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. Author manuscript; available in PMC: 2012 Nov 14.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Dec 13;33(3):408–418. doi: 10.1111/j.1530-0277.2008.00860.x

Fig. 3.

Fig. 3

Clonidine-ethanol synergistic behavioral interaction does not depend on activation of the I1-imidazoline receptor. Rotorod time courses (A), corresponding area under the curve (AUC, B), and LORR durations (C) are shown for groups pretreated i.c. with aCSF prior to 2 i.v. injections of: (i) 300 μg/kg rilmenidine (I1 agonist) + saline (Ril or Rilmenidine) or (ii) 300 μg/kg rilmenidine (I1 agonist) + 1 g/kg ethanol (Ril + EtOH). The Sal and EtOH groups are replotted from Fig. 1. The number of animals per group is shown in parentheses above the bar graphs. LORR data did not reach significance due to unequal variance.