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. 2012 Oct 18;4(10):862–877. doi: 10.3390/toxins4100862

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Vixapatin inhibition of HT1080 cells and MDA-MB-231 cell migration. Migration of: (A) HT1080 cells across the filters coated with collagen I, (B) HT1080 cells across the filters coated with collagen IV; (C) MDA-MB-231 cells across the filters coated with collagen I; (D) MDA-MB-231 cells across the filters coated with collagen IV, in the presence of different concentrations of Vixapatin. Vixapatin was used as chemoattractant and was added to the lower chamber, while the cells were in the upper chamber and the filter coated with respective collagens. Inset: lack of cell migration when Vixapatin and HT1080 cells were applied in the upper chamber. The data are presented as the mean number of migrating cells with SD from three independent experiments. * p < 0.05 compared with the control group.