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Inhibition of programmed necrosis by murine CMV. Death receptor-induced programmed necrosis is mediated by RIP1 and RIP3 and can be activated when caspase-8 activity is blocked. M45 binds to RIP1 and RIP3, inhibits their complex formation, and the induction of death receptor-induced programmed necrosis. M45 also suppresses virus‑induced programmed necrosis, which is mediated by DAI and RIP3, both of which are targeted by M45.
