Fig 3.

PET/CT imaging of M. tuberculosis-infected mice with discrete TB lesions, central necrosis, and hypoxia. Uninfected (A) and infected (B) C3HeB/FeJ pairs were imaged after injection of 2-[¹⁸F]-FDG (A) or 2-[¹⁸F]-INH (B). Whole-animal sagittal and transverse sections are displayed as combined PET/CT images with heart (H), liver (L), kidneys (K), and bladder (B) marked. Discrete foci of 2-[¹⁸F]-INH-PET activity colocalizing with the TB lesions (as seen on CT) is noted in the lung fields of the infected (B) but not the uninfected mouse (A), suggesting that 2-[¹⁸F]-INH penetrates and concentrates at the site of TB lesions. Uptake in the heart, liver, kidneys, and bladder is noted in both infected and uninfected animals.