Fig 3.

Drug toxicity assessment assays. (A) ALT measurements (means ± SEM) in serum from mice treated with 300-mg/kg/day doses of TDF (white bar), (−)-FTC (light gray bar), or a combination of TDF plus (−)-FTC (dark gray bar) at week 51 postinjection of HepAD38 cells. ALT values for mice injected with PBS or with TDF alone were indistinguishable from those reported here. (B) Wet weights of tumors recovered from nude mice bearing HepAD38 xenografts. Mice were treated with 300-mg/kg/day doses of TDF (white bar), (−)-FTC (light gray bar), or a combination of TDF plus (−)-FTC (dark gray bar). Tumor weights were evaluated at week 51 after subcutaneous injection of AD38 cells. Wet weights of tumors derived from mice injected with PBS or with TDF alone were indistinguishable from those reported here. The average is based upon data from 5 mice in each group. IQ, interquartile.