Table 2.
Antibacterial activities of moxifloxacin (MXF), imipenem (IMI), and ertapenem (ERTA) against mixed bacterial cultures in an in vitro model simulating free drug concentrations in pancreatic tissue
| Drug |
E. coli + E. cloacae |
E. coli + E. faecalis |
E. coli + B. fragilis |
|||
|---|---|---|---|---|---|---|
| log10 ΔCFU (h)a | Regrowth (fold) after 24 h | log10 ΔCFU (h)a | Regrowth (fold) after 24 h | log10 ΔCFU (h)a | Regrowth (fold) after 24 h | |
| MXF | −>6 (4)/−>6 (4) | +2/+6 | −>6 (2)/−4 (8) | +2/+2.3 | −>6 (2)/−3 (6) | +2/0 |
| IMI | −4 (6)/−3 (6) | +2/+4 | −5.5 (10)/−2 (8) | +3/+3 | −5 (6)/−2.5 (8) | +2/0 |
| ERTA | −5.3 (4)/−5.3 (4) | +3.1/+6.6 | −4.5 (4)/+1.6 (4) | +3.4/+2.5 | −5.4 (4)/−2.1 (6) | +2/0 |
a
Maximal reduction (negative values) or growth (positive values) of viable counts in the indicated time.