Table 2.
Antimicrobial peptides used in this study
| Peptide | Sequence | FCharge (pH 7)c | Hydrophilic vol (Å)d | Referencee |
|---|---|---|---|---|
| HH18 | IWVIWRR-NH2a | 3 | 965.1 | Unpublished |
| CP10A | ILAWKWAWWAWRR-NH2 | 4 | 1,255.1 | 11 |
| Indolicidin | ILPWKWPWWPWRR-NH2 | 4 | 1,027.3 | 36 |
| HH2 | VQLRIRVAVIRA-NH2 | 4 | 1,317.6 | Unpublished |
| HH17 | KIWVRWK-NH2 | 4 | 980.4 | Unpublished |
| Pleurocidin | GWGSFFKKAAHVGKHVGKAALTHYL | 4 | 1,938.0 | 8a |
| Bac2A | RLARIVVIRVAR-NH2 | 5 | 1,169.9 | 42 |
| Polymyxin B | fa-BTB(BBFDLBBT)b | 5 | 305.9 | 41 |
| Colistin | fa-BTB(BBLDLBBT) | 5 | 1,144.8 | 41 |
| IDR-1002 | VQRWLIVWRIRK-NH2 | 5 | 1,269.8 | 30 |
| IDR-1012 | IFWRRIVIVKKF-NH2 | 5 | 1,147.9 | Unpublished |
| IDR-1018 | VRLIVAVRIWRR-NH2 | 5 | 1,072.1 | 38 |
| HHC36 | KRWWKWWRR-NH2 | 6 | 1,426.4 | 4 |
| IDR-1010 | IRWRIRVWVRRI-NH2 | 6 | 1,431.1 | Unpublished |
| IDR-1020 | VRLRIRWWVLRK-NH2 | 6 | 1,398.4 | Unpublished |
| CP29 | KWKSFIKKLTTAVKKVLTTGLPALIS | 6 | 1,329.9 | 12 |
| CRAMP | GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ | 6 | 2,908.1 | 13 |
| CP26 | KWKSFIKKLTSAAKKVVTTAKPLISS | 7 | 1,362.1 | 12 |
| CP28 | KWKLFKKIGIGAVLKVLTTGLPALKLTK | 7 | 1,145.4 | 32 |
a
Sequence in the one-letter amino acid code; NH2 indicates the amidation of the carboxyl terminus.
b
Sequence in the one-letter amino acid code; B indicates positively charged α,γ-diaminobutyrate; a superscript D indicates that amino acid is the d-enantiomer; fa indicates a 6-methyloctanoyl or 6-methylheptanoyl fatty acid chain.
c
Sum of formal charges, descriptor 83 (FCharge) calculated using MOE software.
d
Hydrophilic volume, descriptor 247 (vsurf_W3).
e
Unpublished, R. E. W. Hancock and K. Hilpert, unpublished data.