Fig 1.
Survival rates for rats (n = 16) immunosuppressed with cortisone acetate and infected intratracheally with A. fumigatus conidia (5 ×107 conidia in 0.2 ml of saline) and then treated with saline or PTX3, VRC, or a combination of the two, as indicated. (Left) Survival of rats receiving the combination of PTX3 at 0.15 mg/kg and VRC at 20 mg/kg and the corresponding single treatments. (Right) Effects of the combination of PTX3 at 1.5 mg/kg and VRC at 20 mg/kg and the corresponding single treatments. The PTX3 administration schedule was begun on day 3 before lung infection until day 3 after lung infection. Voriconazole was administered on the day of infection and then once daily for the next 8 days. The same administration schedule for each compound was maintained for the drug combinations. *, P < 0.05, and **, P < 0.001, based on Kaplan-Meier analysis.