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. 2012 Oct 8;13(10):12857–12879. doi: 10.3390/ijms131012857

Figure 1.

Figure 1

Structure Beta secretase-1 (BACE-1). (a) Overall fold showing location of active site; (b) Active site residues; (c) Hydroxyethylamine-based peptidomimetic inhibitor; (d) Same compound shown in BACE-1. Sub-sites are labeled according to the amino-acids either side of the cleavage site (S2, S1, S1′, S2′, etc.).