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Chemical structures of high-affinity BACE-1 inhibitors. The structural formulae of the protonated forms of the compounds bound are shown, and, where determined, IC50 values and crystal structures of complexes with BACE-1 are shown. (a) 3-((3-(1H-indol-6- yl)benzyl)amino)-2-aminopyridine; (b) 3-((5-(1H-indol-6-yl)-2-(pyridin-2-ylmethoxy) benzyl)amino)-2-aminopyridine; (c) 2-amino-3-((2-(benzyloxy)-5-(1H-indol-6-yl)benzyl) amino)pyridine.
