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Course of B. melitensis infection in the spleen of wild-type and Th response-deficient BALB/c mice. Wild-type, IL-12p40−/− (Th1 and Th17), and IL-4R−/− (Th2) BALB/c mice were injected i.p. with 4 × 104 CFU of B. melitensis and euthanized at the indicated times. The data represent the number of CFU per gram of spleen. Gray bars represent the medians. These results are representative of two independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
