Fig 1.

Fungal burden and dissemination following C. neoformans infection. Inbred 7-week-old female C3H/HeN and CBA/J mice underwent intratracheal infection with 10⁴ CFU of C. neoformans ATCC 24067. (A) Fungal burden in the lung was determined at 7, 14, 21, 28, and 56 days after infection. (B) Fungal burden in the spleen and brain was determined 28 days after infection. Each filled circle represents an individual mouse; horizontal bars represent the mean number of CFU/organ (n = 4 or 5 mice/strain/day; *, P = 0.01; **, P < 0.01; ***, P < 0.001).