Fig 5.
Histopathology in C. difficile (VPI 10463)-infected A2BAR knockout (KO) and littermate C57BL/6 wild-type (WT) mice. (A) Representative H&E-stained tissue sections from cecal specimens obtained during sacrifice of moribund mice or of surviving mice at the end of the observation period. (B) Cecal histopathology scores (P = 0.0047 by ANOVA with Bonferroni's multiple comparison test). n = 7 to 9 in the control group, and n = 10/group in infected groups. Survival, clinical and diarrhea scores, C. difficile shedding, and toxin burden are presented in Fig. 4.