TABLE 2.

The Relationship Between Insulin Sensitivity and Markers of Thrombosis and Inflammation^a

Variableb,c	Pearson correlation		Partial (adjusted) correlation
	r	P value	r	r2	P value
Lipid profile
Triglycerides (mg/dL)	−0.319	.04	−0.322	0.104	.05
HDL-C (mg/dL)	0.527	<.001	0.461	0.213	.003
Non–HDL-C (mg/dL)	−0.191	.23	−0.222	0.049	.18
Thrombotic markers
Fibrinogen (mg/dL)d	−0.191	.23	−0.198	0.039	.24
PAI-1 (ng/dL)d	−0.588	<.001	−0.492	0.242	.001
AT-III (% activity)	0.092	.56	−0.073	0.005	.66
Inflammatory markers
CRP (mg/dL)d	−0.214	.17	−0.207	0.043	.21
IL-6 (pg/mL)d	−0.594	<.001	−0.541	0.293	<.001
TNF-α (pg/mL)d	−0.419	.006	−0.420	0.177	.007
Adiponectin (mg/mL)d	0.634	<.001	0.619	0.383	<.001

^aAT-III = antithrombin III; BMI = body mass index; CRP = C-reactive protein; HDL-C = high-density lipoprotein cholesterol; IL-6 = interleukin 6; NEA = Northern European Americans without diabetes; PAI-1 = plasminogen activator inhibitor 1; TNF-α = tumor necrosis factor α.

^bSI conversion factors: To convert triglyceride levels to mmol/L, multiply by 0.0113; to convert HDL-C levels to mmol/L, multiply by 0.0259; to convert non–HDL-C levels to mmol/L, multiply by 0.0259; to convert fibrinogen levels to μmol/L, multiply by 0.0294; and to convert CRP levels to mg/L, multiply by 10.

^cInsulin sensitivity was calculated as mean rate of glucose infusion maintaining euglycemia during hours 4 through 8 of an 8-hour insulin infusion, when steady-state dynamics have been achieved. Partial correlation reflects adjustment for age, sex, and BMI. The r² value is the partial coefficient of determination, adjusted for age, sex, and BMI.

^dInflammatory markers and coagulation factors were log transformed to minimize effect of outlying values.