Fig 1.

Enriched Tlx expression in malignant human gliomas. (A) Relative Tlx expression in human tissues by qRT-PCR analysis. Bar 1, fetal brain (n = 1); 2, adult brain (n = 1); 3, pillocytic astrocytoma (grade I; n = 15); 4, oligodendroglioma (grade II; n = 12); 5, oligodendroglioma (grade II/III; n = 4); 6, oligodendroglioma (grade III; n = 19); 7, glioblastoma (grade IV; n = 20); 8, dysembryoplastic neuroepithelial tumor (n = 8); 9, meningioma (n = 18); 10, malignant meningioma (n = 6); 11, null cell pituitary adenoma (n = 5); 12, medulloblastoma (n = 3); 13, acoustic schwannoma (n = 5); 14, papilloma (n = 1); 15, ependymoma (n = 2); 16, solitary fibrous tumor (n = 1); 17, normal colon, fat, and liver (n = 7); 18, chordoma (n = 1). The dotted line indicates normal Tlx expression in the adult brain. (B) Expression of stem cell markers in human gliomas. Data were obtained from GEO record GDS1815 by Affymetrix human genome U133A array (n = 24 for grade III and n = 68 for grade IV; *, P < 10⁻⁸; **, P < 10⁻¹²).