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Susceptibility to ETR of WT and mutated viruses
| Virus | EC50 (nM)a | FCb |
|---|---|---|
| WT | 1.65 ± 0.05 | |
| E138K | 5.4 ± 0.14 | 3.3 |
| Y181C | 9.95 ± 0.35 | 6.0 |
| E138K/Y181C | 8.45 ± 1.5 | 5.1 |
EC50s (50% effective drug concentrations) were determined in a phenotypic cell-based assay. Data are the means and standard deviations (SD) of 3 independent experiments.
FC values are the fold changes in EC50 for mutated viruses compared to the EC50 of the WT.
