Fig 4.

Entry and replication potentials of neutralization-resistant and neutralization-sensitive, revertant viral clones. Replication kinetics in human PBMCs of VC10042 wild-type viral clones VC10042.Y19.72, VC10042.Y19.205, VC10042.y22.04, and VC10042.y22.05 and of their corresponding R373M reversion variants are shown. Closed circles and solid lines, wild type; open circles and dotted lines, paired R373M reversion mutant. Results from two independent replication trials performed in PBMCs from two different donors (A to D and E to H) are shown. The average p24 concentrations and the standard deviations from replicate wells in duplicate experiments are shown.