Table 1.
Entry of individual plasma viral clones into U87 cells
| ypia | Envelope clone | Viral entry (RLU) into U87 cells at 3 ng p24 with the following receptor/coreceptor combinationb: |
||||
|---|---|---|---|---|---|---|
| CD4 | CD4/CCR5 | CD4/CXCR4 | CCR5 | CXCR4 | ||
| 19 | VC10042.y19.48 | — | 79,530 | — | — | — |
| VC10042.y19.72 | — | 4,834,620 | — | — | — | |
| VC10042.y19.101 | — | 3,544,620 | — | — | — | |
| VC10042.y19.113 | — | 746,125 | — | — | — | |
| VC10042.y19.205 | — | 5,224,620 | — | — | — | |
| 22 | VC10042.y22.01 | — | 1,428,341 | — | — | — |
| VC10042.y22.02 | — | 2,052,091 | — | — | — | |
| VC10042.y22.03 | — | 1,888,341 | — | — | — | |
| VC10042.y22.05 | — | 2,192,091 | — | — | — | |
| VC10042.y22.06 | — | 1,062,591 | — | — | — | |
| VC10042.y22.07 | — | 3,079,591 | — | — | — | |
| VC10042.y22.08 | — | 155,461 | — | — | — | |
| VC10042.y22.e1 | — | 190,561 | — | — | — | |
a
Clones were isolated from plasma collected at the indicated year postinfection.
b
Each clone was tested for its ability to enter into U87 cell lines bearing the indicated combinations of CD4 receptors and the CCR5 and CXCR4 coreceptors. Values reported are the relative light units (RLU) obtained by viral entry into the target cell. —, no entry was observed above background, relative to negative controls (RLU recorded with viral particles not expressing HIV env).