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. 2012 Dec;86(23):13085–13088. doi: 10.1128/JVI.01939-12

Fig 3.

Fig 3

Escape mutants of MAb AP33. Binding of MAb AP33 to alanine scanning mutants of E2 region 412 to 423 (A) or mutants with a substitution at position 415 (B) or 655 (C). (D) Resistance to MAb AP33 by mutations leading to loss of binding. The antibody used in this study (huAP33) is a chimeric form of the MAb, with the murine variable domains fused to human kappa LC and IgG1 HC constant regions. Functional verification of this chimeric MAb is provided in Fig. S1 in the supplemental material.