Fig 2.

IRF-1 is critical for resistance to lethal infection with MNV when IFN-ɑβ signaling is inhibited. WT, IRF1^−/−, and IFN-γR^−/− mice were treated with a control or anti-IFNAR MAb, inoculated with 3 × 10⁵ PFU of MNV, and monitored for survival for 21 days. Seven mice were used per group, and data represent at least three independent experiments. Survival differences between anti-IFNAR MAb-treated WT and IRF-1^−/− mice were significant (P = 0.0003).