Fig 5.

Inhibition of MNV replication in IFN-γ-activated macrophages is STAT-1 dependent but IFN-αβR, CIITA, IRF-3, and IRF-7 independent. IFN-αβR^−/−, CIITA^−/−, IRF3×7^−/−, and STAT-1^−/− macrophages were treated with increasing doses of IFN-γ or medium alone before inoculation at an MOI of 5 (A) or 0.05 (B). These experiments were conducted concurrently with the experiments for Fig. 4; therefore, the data for WT macrophages are repeated in the figure for comparison. Data were collected from at least three independent experiments. Asterisks indicate significant differences in viral titers relative to those in WT cells (*, P < 0.05; **, P < 0.01; ***, P < 0.001).