Table 2.
Mutation | Average no. of mutant copies/ml (average % mutant frequency across 80 wells) |
|||
---|---|---|---|---|
Week 1 (2.9 × 106)a | Week 13 (1.6 × 106) | Week 14 (9.7 × 104) | Week 16 (1.5 × 106) | |
K65Rb | 418 (0.01) | 78 (0.005) | 4 (0.004) | 304 (0.02) |
K103N (AAC)b | <29 (<0.001) | <17 (<0.001) | 11,154 (11.5) | 139,500 (9.3) |
K103N (AAT)b | <29 (<0.001) | <17 (<0.001) | 6,111 (6.3) | 39,000 (2.6) |
M184Ib | <29 (<0.001) | 520 (0.004) | <1 (<0.001) | 356 (0.015) |
Viral RNA copy number/ml in plasma.
The assay background for K65R, K103N AAC and AAT, and 184I was 0.0001% across 80 wells.