Fig 3.

Effects of vaccine doses on magnitudes of elicited HIV-specific T cell responses. Frequencies of total (Gag and Env) HIV-specific CD8 (left) and CD4 (right) T cell responses were determined by IFN-γ ICS assays of PBMCs from rhesus macaques at the indicated times following high-dose (2 × 10⁸ PFU) or low-dose (1 × 10⁷ PFU) immunization with the MVAΔ4-HIV, MVAΔ5-HIV, or MVA-HIV vector at weeks 0 and 9 (arrows). Horizontal lines denote group geometric mean responses. Statistical comparisons of groups were performed via a Kruskal-Wallis test. High-dose data are reproduced from Fig. 1 to facilitate comparisons. Note the different ordinate scales between the CD8 and CD4 plots.