Fig 7.

The conserved hydrophobic groove in H16HA0 reveals the structural basis of binding with the broadly neutralizing antibody FI6. Surface representations of the F subdomains of 09H1 HA (A) and H16HA0 (B) with selected side chains that contribute to the conserved hydrophobic groove are shown. The approximate boundaries of the hydrophobic grooves are indicated by the black lines. Although the residues contributing to the hydrophobic groove are moderately different between 09H1 and H16, similar hydrophobic grooves guarantee the binding potential by the FI6 antibody.