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. 2012 Dec;86(23):12770–12778. doi: 10.1128/JVI.01545-12

Fig 3.

Fig 3

The majority of the human proteins in the HSV-1-induced secretome have an intracellular localization and are known exosomal proteins. (A) Classification of the secretome proteins on the basis of the GO annotations for their cellular compartment. (B) Classification of the intracellular proteins into different cellular organelles in the IFN-β-primed, HSV-1-infected, and IFN-β-primed plus HSV-1-infected macrophage secretomes. ER, endoplasmic reticulum. (C) Classification of all the identified proteins and proteins with an FC of >2 in the secretome with SignalP and ExoCarta to determine classically and exosomally secreted proteins, respectively. GO annotations were done using GeneTrail, classically secreted proteins were predicted using SignalP (version 4.0), and exosomal proteins were identified using the ExoCarta (version 3.1) database.