TABLE 2.

Diffuse Large B-Cell Lymphoma in the New World Health Organization Classification

•Centroblastic •Immunoblastic •Anaplastic •Plasmablastic •T-cell rich •ALK-positive •CD5-positive •GCB •Non-GCB

•Primary CNS •Primary cutaneous, leg type •Mediastinal •Intravascular •Primary effusion

•EBV-positive in elderly •With chronic inflammation •Lymphomatoid granulomatosis •In HHV-8 associated Castleman disease

ALK = anaplastic lymphoma kinase; CNS = central nervous system; EBV = Epstein-Barr virus; GCB = germinal center B-cell; HHV-8 = human herpesvirus 8.