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. 2012 Oct 19;32(6):619–629. doi: 10.1042/BSR20120042

Figure 4. Perinatal exposure to MEHP induces obese phenotype in male offspring.

Figure 4

Pregnant mice were dosed by gavage with vehicle (olive oil) or MEHP (0.5, 0.25 or 0.05 mg/kg of b.w.) from E12 until the 7th day of lactation (PND 7 of offspring). Obesity parameters of 8-week-old male offspring were measured. (A) b.w. (B) Liver weight. (C) Epididymal fat pad weight. (D) Perirenal fat pad weight. (E) The percentage of adipose tissue weight to b.w. (F) Serum levels of total cholesterol. (G) Serum levels of TAGs. (H) Serum glucose levels. Values are means±S.E.M. (n=16 vehicle-treated male pups from five litters; n=12 MEHP-treated (0.05 mg/kg of b.w.) male pups from three litters; n=14 MEHP-treated (0.25 mg/kg of b.w.) male pups from three litters; n=13 MEHP-treated (0.5 mg/kg of b.w.) male pups from three litters). *P<0.05, **P<0.01, ***P<0.001.