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Spatiotemporal profiles of PKA activation by TNS. (A) PKA activation is observed immediately and at 1 h after repeated TNS in synaptic neuropil (Syn. NP), whereas in SN soma PKA activation is delayed, observed at 1 h post TNS. (B) A single TNS induces transient PKA activation in synaptic neuropil that returns to baseline by 15 min. (C) The transient PKA activation in synaptic neuropil by a single TNS is blocked by H89, a PKA inhibitor.
