Fig. 4.

Shorter LN dwell times of CD4⁺ T cells in the absence of MHCII but not of CD8⁺ T cells in the absence of MHCI. (A and C) CD4:CD8 ratio of adoptively transferred T cells in i/bLNs at various times after entry blockade in WT and MHCII^−/− or MHCI^−/− mice. (B and D) Mean LN dwell time estimates for transferred naïve CD4⁺ and CD8⁺ T cells. Circles denote transit time estimates from one experiment. Lines represent group means from five to seven independent experiments. Closed symbols, iLN; open symbols, bLN. In D: ●, β₂M^−/−- or WT-matched recipients; ▲, K^bD^b−/−- or WT-matched recipients.