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Wnt/β-catenin signaling. (A) The canonical Wnt signaling pathway with its major components in the inactive (Left) and active (Right) state. BCL9 and CBP are transcriptional coactivators. (B) Superimposed crystal structures of the β-catenin armadillo domain bound to the CBDs of Axin (PDB ID 1QZ7) (18) and TCF4 (PDB ID 2GL7) (17).
