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(A) Typical unfolding/refolding traces obtained in a force-ramp experiment for A7C/N59C src SH3 (black/gray) and R19C/N59C src SH3 (red/pink). A single protein molecule is stretched (loading rate 8 pN/ sec) until the unfolding event is seen as a “rip” (indicated by arrows). The protein is then allowed to refold by moving the trap to low forces. (B) Histogram of unfolding forces for A7C/N59C src SH3 (black, Fu = 35 ± 0.5 pN) and R19C/N59C src SH3 (red, Fu = 14 ± 0.3 pN).
