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Knotting, folding, and unfolding events observed for 2ouf-12aa. Trajectory insets show (Top Left) random knotting by the C-terminal, (Top Middle) folding via knotting at low Q (unique to 2ouf-12aa), and (Top Right) unknotting and unfolding by unplugging the N-terminal. Corresponding configurations are shown next to the insets. (Bottom) Topological signature of the protein measured by the position of the knot along the sequence. Knot termini are shown by blue and red dots.
