Table 1.
Relationship between coded and actual values of the variables used for PLGA-CURC formulation
|
Formulation factors |
Coded level of variables |
||||
|---|---|---|---|---|---|
| -α | −1 | 0 | 1 | +α | |
|
X1 = Amount of PLGA (mg) |
26.14 |
50 |
85 |
120 |
143.86 |
|
X2 = PVA (% w/v) |
0.32 |
1.0 |
2.0 |
3.0 |
3.68 |
|
X3 = Ethyl acetate (ml) |
0.98 |
2 |
3.5 |
5.0 |
6.02 |
|
Dependent variables |
Constraints |
||||
|
Y1 = Particle Size (nm) |
Minimize |
||||
|
Y2 = Polydispersity |
Minimize |
||||
|
Y3 = Encapsulation efficiency (%) |
Maximize |
||||
| Y4 = Drug loading (%) | Maximize | ||||