Table 4.

Scale up results for large batch production of PLGA-CURC

	Particle size (nm)	Polydispersity index	Encapsulation efficiency (%)	Drug loading (%)
Primary optimized conditions	129.5 ± 6.9	0.138 ± 0.023	91.4 ± 2.3	12.68 ± 3.5
First stage – 500 mg	135.4 ± 9.4	0.139 ± 0.012	91.12 ± 1.5	11.98 ± 2.5
Second stage – 1 g	142.3 ± 8.9	0.142 ± 0.024	92.13 ± 3.5	11.12 ± 2.6
Third stage- 2 g	148.6 ± 7.7	0.137 ± 0.025	90.67 ± 2.8	10.92 ± 2.3
Fourth stage – 5 g	158.5 ± 9.8	0.141 ± 0.011	90.34 ± 3.2	10.32 ± 1.4