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Representative frames showing cell dispersion from neurospheres seeded on aligned (A) and random (B) PCL fibers. The corresponding bounding ellipses were estimated by principal component analysis. The change in the ratio of the elliptic axes over time (i.e., a measure of anisotropic cell spread) revealed a sixfold increase in along-axis versus across-axis migration on aligned fibers (C). Color images available online at www.liebertonline.com/ten.
