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PK parameters for melperone treatments A (25-mg Syrup; 50-mg Syrup), B (50-mg ODT-CR 1), C (50-mg ODT-CR 2), and D (50-mg CR Capsule).
| PK Parameters, mean (RSD) | Treatment A |
Treatment B |
Treatment C |
Treatment D |
|
|---|---|---|---|---|---|
| 25-mg Syrup | 50-mg Syrup | ODT-CR 1 | ODT-CR 2 | CR Capsule | |
| AUC0-last (ng.hr/mL) | 132.7 (42) | 331.3 (14) | 258.9 (41) | 264.6 (44) | 252.1 (43) |
| Cmax (ng/mL) | 19.3 (37) | 58.8 (26) | 20.0 (30) | 16.2 (32) | 17.0 (34) |
| Tmax (hr) | 1.8 (34) | 1.0 (35) | 4.9 (18) | 5.9 (24) | 5.8 (15) |
