TABLE 5.
Chromosomal regions that exhibited significant (LOD ≥3.6) and suggestive (LOD ≥2.2) linkage to BMI1
| LOD scores |
||||||
| Region | BMI-zadj (402 pairs) | BMI-zadj-PI (358 pairs) | BMI-zadj-F508del (219 pairs) | BMI-zadjFEV (393 pairs) | BMI-zadjFEV-PI (350 pairs) | BMI-zadjFEV-F508del (213 pairs) |
| 1p36.1 | 4.82 | 5.32 | 4.62 | 3.2 | 3.4 | 3.82 |
| 1p31-22 | — | — | — | 3.0 | 2.4 | 2.9 |
| 2q14.3 | — | — | — | — | — | 2.3 |
| 5q14 | 3.62 | 5.12 | 3.4 | 3.2 | 5.22 | 3.3 |
| 6q25 | — | — | — | 2.5 | 2.3 | — |
| 7q33 | 2.8 | — | — | 2.9 | — | 2.4 |
| 9q34 | — | — | 2.5 | — | — | 2.7 |
| 10q25-26 | — | — | 2.5 | — | — | 2.6 |
| 11q12 | 2.7 | — | — | 2.3 | — | — |
| 11q14 | — | 3.2 | 3.4 | — | 2.7 | 3.82 |
| 12p12 | — | — | — | — | 2.5 | — |
| 13q33 | — | — | 2.5 | — | — | — |
| 14q21 | — | — | 2.5 | — | — | 3.62 |
| 16p11.2 | 2.7 | — | — | — | — | — |
BMI-zadj, average BMI z score from 5 to 10 y of age adjusted for female sex, birth cohort, pancreatic insufficiency, and history of meconium ileus; BMI-zadjFEV, average BMI z score from 5 to 10 y of age adjusted as for BMI-zadj plus for FEVq6to10; BMI-zadjFEV-F508del, BMI-zadjFEV values with the inclusion of only subjects homozygous for F508del; BMI-zadjFEV-PI, BMI-zadjFEV values with the inclusion of only pancreatic-insufficient subjects; BMI-zadj-F508del, BMI-zadj values with the inclusion of only subjects homozygous for F508del; BMI-zadj-PI, BMI-zadj values with the inclusion of only pancreatic-insufficient subjects; LOD, log of odds.
LOD score met or exceeded genome-wide significance (36).