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Articular cartilage erosion and fibrillation and fibrous tissue development were grossly evident after anterior cruciate ligament transection (ACLT). Selected gross images of rat knee femurs after 6 and 12 weeks of standardized exercise. Erosions (arrowheads) and fibrous tissue development (arrow) were observed in the ACLT group at both time points. Pannus formation was observed in 1 of 6 sham animals at 12 weeks.
