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Serum CS846 is elevated with mild cartilage degeneration. Serum CS846 levels increased following anterior cruciate ligament transection (ACLT) or sham surgery after 6 weeks of exercise in all groups (by Kruskal-Wallis reported on the graph) with intergroup comparisons assessed by the Wilcoxon rank test. After 12 weeks of exercise, the concentration of CS846 returned to preoperative levels (*P < 0.05).
