TABLE.
Proposed Clinical Criteria for Diagnosis of Cannabinoid Hyperemesis in 2 Patients
| Criterion | Patient 1 | Patient 2 |
|---|---|---|
| Essential for diagnosis | ||
| Long-term cannabis use | Yes (2–3 y) | No (only 3 mo) |
| Major features | ||
| Severe cyclic nausea and vomiting | Yes | Yes |
| Resolution with cannabis cessation | NA | NA |
| Relief of symptoms with hot showers or baths | Yes | Yes |
| Abdominal pain, epigastric or periumbilical | Yes | Yes |
| Weekly use of marijuana | Yes | Yes |
| Supportive features | ||
| Age <50 y | Yes | Yes |
| Weight loss >5 kg | NA | Yes |
| Morning predominance of symptoms | NA | NA |
| Normal bowel habits | Yes | No (diarrhea) |
| Negative laboratory, radiographic, and endoscopic test results | Yes | No (pending) |
NA = not available.
Data from Mayo Clinic Proceedings.1