Figure 2.

Estimate of treatment effect on recurrence of hospitalizations for worsening heart failure (total-time approach). The approach allows for a cumulative effect in which the second hospitalization includes the effect of the first, and the third hospitalization includes the effects of the first and second. All data adjusted for prognostic factors at the baseline (β-blocker, New York Heart Association class, left ventricular ejection fraction, ischaemic cause of heart failure, age, systolic blood pressure, heart rate, and creatinine clearance).