Table 2.

Dantrolene Doses

Full Dataset Dose Type	N	Median	25%	75%	Range
Total Dose, mg	368	234.0	100.0	600.0	2.0 – 6,720
Total Dose, mg/kg	368	4.9	2.5	9.0	0.02 – 100
Initial Dose, mg/kg	364	2.4	1.7	2.7	0 – 15.0
Reduced Dataset Dose Type	N	Median	25%	75%	Range
Total Dose, mg	349	222.0	94.5	600.0	2.0 – 6,720
Total Dose, mg/kg	349	4.7	2.5	8.7	0.02 - 100
Initial Dose, mg/kg	345	2.4	1.6	2.6	0 – 15.0

Dantrolene doses were reported in the AMRA (adverse metabolic/musculoskeletal reaction to anesthesia) as initial dose and total dose. There were cases in which one of these two was not reported. Therefore, the Total Dose was defined as the total dose when reported or the initial dose if no other dose was reported. This definition of total dose is the variable used in regression analysis. There was no significant difference between the full and reduced datasets for any of these dantrolene doses.