Table 1. Results for associations between mother and child genotypes and total WISC score at age 8.

Gene	SNP-rsnumber	Rare allele freq	HWEp-value	Mothers drinking (<1–6 units per week)During pregnancy			Mothers not drinking during pregnancy
Mother				N	Per allele effect on WISC (SE)	P-value	N	Per allele effect on WISC (SE)	P-value
ADH4	rs4699714	0.27	0.05	2344	0.14 (0.52)	0.80	1203	−0.47 (0.73)	0.52
ADH4	rs3762894	0.16	0.44	2352	0.63 (0.64)	0.33	1195	0.08 (0.88)	0.93
ADH4	rs4148884	0.08	0.85	2351	−1.53 (0.84)	0.07	1206	−0.94 (1.16)	0.42
ADH1A	rs2866151	0.46	0.44	2304	−1.23 (0.48)	0.01	1181	0.54 (0.66)	0.41
ADH1A	rs975833	0.24	0.13	2323	0.93 (0.57)	0.10	1193	−0.49 (0.78)	0.53
ADH1A	rs1229966	0.36	0.22	2330	1.18 (0.50)	0.02	1191	−0.004 (0.69)	1.00
ADH1B	rs2066701	0.29	0.43	2294	0.43 (0.54)	0.42	1171	−0.003 (0.74)	1.00
ADH1B	rs4147536	0.22	0.70	2326	0.49 (0.58)	0.40	1193	0.179 (0.81)	0.83
ADH1B	rs1229984*group 2&3	0.03	0.57	2346	−1.27 (1.62)	0.43	1195	2.44 (1.94)	0.21
ADH7	rs284779	0.45	0.91	2343	−1.40 (0.48)	0.003	1200	0.77 (0.68)	0.26
Child
ADH4	rs4699714	0.28	0.56	2962	−0.30 (0.47)	0.52	1456	−1.41 (0.66)	0.03
ADH4	rs3762894	0.17	0.01	2940	0.38 (0.55)	0.49	1458	0.09 (0.80)	0.91
ADH4	rs4148884	0.08	0.75	2959	0.21 (0.76)	0.78	1474	2.48 (1.06)	0.02
ADH1A	rs2866151	0.47	0.16	2903	−0.45 (0.42)	0.29	1433	0.08 (0.61)	0.89
ADH1A	rs975833	0.24	0.74	2926	−0.32 (0.50)	0.52	1450	−0.06 (0.69)	0.94
ADH1A	rs1229966	0.37	0.39	2933	0.40 (0.44)	0.36	1461	0.10 (0.62)	0.87
ADH1B	rs2066701	0.29	0.43	2886	0.02 (0.47)	0.97	1429	−0.06 (0.66)	0.92
ADH1B	rs4147536	0.20	0.49	2945	0.13 (0.53)	0.80	1453	−0.20 (0.73)	0.78
ADH1B	rs1229984*group 2&3	0.03	0.57	3364	−1.06 (1.26)	0.40	1702	2.02 (1.61)	0.21
ADH7	rs284779	0.45	0.01	2945	−1.27 (0.41)	0.002	1465	0.29 (0.60)	0.63

A linear regression model was used for this analysis, *Dominant effect.