Figure 4. Kinase inactive Jak2 is degraded but not aggregated.

γ2A Jak2 −/− were transiently transfected with Jak2-K882E or wild type Jak2, respectively. Equal amounts of cells were incubated at 37 and 40°C, respectively, for the indicated times. The cells were lysed, fractionated and analyzed as in Fig. 3B. The data in this figure are representative of three independent experiments.