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Comparison of Cladribine and Pentostatin
| Variable | Cladribine | Pentostatin |
|---|---|---|
| Dose | 0.1 mg/kg per day for 7 days | 4 mg/m2 every other week for 8-12 doses |
| Route | IV (continuous or bolus), subcutaneous, or oral | IV bolus |
| CR rate, % | 79-98 | 72-79 |
| Notable toxic effects | Febrile neutropenia, myelosuppression, immunosuppression | Nausea, rash, myelosuppression, immunosuppression |
| PFS at 4 years, % | 50-88 | 72-76 |
CR = complete response; IV = intravenous; PFS = progression-free survival.
