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. 2012 Nov 14;7(11):e49606. doi: 10.1371/journal.pone.0049606

Figure 3. Favorable effects of the Mclk1 +/− genotype on fibrosis and plasma ALT levels during aging and after repeated S. Enteritidis infection.

Figure 3

A. The Level of liver fibrosis in wild type C57BL/6J mice of different age was determined. Sample sizes were from 5 to 16 and the means ± S.E.M. of each age group is shown. The asterisks indicate statistical significance compared to the immediately younger age group by a t-test. * stands for P<0.05, ** for P<0.01, and *** for P<0.001. B. Plasma ALT activity of wild type C57BL/6J mice was measured and the mean ± S.E.M. of each age group is shown. Sample sizes were from 5 to 14. C. The level of liver fibrosis in young and old Mclk1 +/− mutants on the C57BL/6J background and their Mclk1 +/+ siblings was determined. Sample size was 5 for the 3 months-old cohort and from 17 to 20 for the 23 months-old cohort. D. ALT activity in Mclk1 +/− mutants and Mclk1 +/+ siblings on the C57BL/6J background was measured at 3 months and 23 months of age. There were 5 mice for each genotype in the 3 months-old cohort, and from 15 to 16 mice in the 23 months-old cohort. E. The level of liver fibrosis was determined after 3 rounds of S. Enteritidis infection. There were 11–16 mice in each group; the mean ± S.E.M. of each group is shown. The asterisks indicate statistical significance compared to the wild type group by a t-test. * stands for P<0.05. All experiments in this figure were carried out with even numbers of both males and females.