. 2012 Nov 14;7(11):e49032. doi: 10.1371/journal.pone.0049032

Table 2. Stratification analyses of genetic susceptibility of rs11614913 polymorphism to cancer risk.

Category	Cases/Controls	TT vs. CC			CT vs. CC			TT+CT vs. CC			TT vs. CC+CT
		OR(95% CI)	P ^a	I ²	OR(95% CI)	P ^a	I ²	OR (95% CI)	P ^a	I ²	OR(95% CI)	P ^a	I ²
Total	12663/14739	0.83(0.74,0.93) ^b	0.001	52.5	0.98(0.90,1.07)^b	0.004	47.5	0.94(0.86,1.02)^b	0.001	53.8	0.86(0.79,0.95) ^b	0.005	46.7
Cancer types
Breast cancer	3722/4712	0.81(0.61,1.09)^b	0.014	68	0.94(0.85,1.04)	0.532	0	0.91(0.83,1.00)	0.148	41	0.87(0.70,1.08)^b	0.027	63.5
Colorectal cancer	1397/2040	0.70(0.57,0.85)	0.284	21.1	0.81(0.65,1.08)	0.367	5.2	0.77(0.65,0.91)	0.377	3.1	0.80(0.69,0.94)	0.198	35.7
HCC	1015/999	0.74(0.47,1.19)^b	0.022	69	0.90(0.72,1.11)	0.631	0	0.85(0.69,1.04)	0.19	37	0.18(0.57,1.15)^b	0.037	64.6
Lung cancer	2118/2103	0.77(0.65,0.91)	0.895	0	0.90(0.77,1.04)	0.098	57	0.85(0.74,0.98)	0.289	19.4	0.83(0.73,0.95)	0.281	21.3
Gastric cancer	765/910	0.80(0.61,1.06)	0.306	4.5	0.84(0.65,1.08)	0.163	48.5	0.82(0.65,1.04)	0.162	48.8	0.89(0.72,1.11)	0.698	0
Other cancers	3646/3975	1.06 (0.91,1.23)	0.125	38.2	1.23(1.10,1.37)	0.239	23.9	1.13(1.03,1.25)	0.096	40.7	0.93(0.74,1.17)	0.024	56.7
Ethnicities
Asian	7837/8878	0.80(0.73,0.88)	0.169	23.7	0.99(0.88,1.13)^b	0.001	57.4	0.95(0.84,1.07)^b	0.001	58.3	0.85(0.80,0.92)	0.3	12.6
Caucasian	4400/5395	0.94(0.71,1.23)^b	0.006	69.7	1.01(0.92,1.04)^b	0.597	0	0.98(0.90,1.07)	0.181	32.3	0.94(0.74,1.21)^b	0.005	70.5
Source of controls
Population based	11123/12811	0.87(0.77,0.98) ^b	0.009	46.7	1.01(0.91,1.11)^b	0.002	52.4	0.97(0.88,1.06)^b	0.001	54.8	0.89(0.82,0.98) ^b	0.024	41.1
Hospital based	1540/1928	0.65(0.53,0.79)	0.111	50	0.85(0.72,1.01)	0.868	0	0.78 (0.67,0.92)	0.585	0	0.74(0.63,0.87)	0.092	53.5

P value of Q-test for heterogeneity test.

Random-effects model was used when a P value<0.05 for heterogeneity test; otherwise, fixed-effects model was used.

I ²: 0–25, no heterogeneity; 25–50, modest heterogeneity; 50, high heterogeneity.