Table 2. Stratification analyses of genetic susceptibility of rs11614913 polymorphism to cancer risk.
Category | Cases/Controls | TT vs. CC | CT vs. CC | TT+CT vs. CC | TT vs. CC+CT | ||||||||
OR(95% CI) | P a | I 2 | OR(95% CI) | P a | I 2 | OR (95% CI) | P a | I 2 | OR(95% CI) | P a | I 2 | ||
Total | 12663/14739 | 0.83(0.74,0.93) b | 0.001 | 52.5 | 0.98(0.90,1.07)b | 0.004 | 47.5 | 0.94(0.86,1.02)b | 0.001 | 53.8 | 0.86(0.79,0.95) b | 0.005 | 46.7 |
Cancer types | |||||||||||||
Breast cancer | 3722/4712 | 0.81(0.61,1.09)b | 0.014 | 68 | 0.94(0.85,1.04) | 0.532 | 0 | 0.91(0.83,1.00) | 0.148 | 41 | 0.87(0.70,1.08)b | 0.027 | 63.5 |
Colorectal cancer | 1397/2040 | 0.70(0.57,0.85) | 0.284 | 21.1 | 0.81(0.65,1.08) | 0.367 | 5.2 | 0.77(0.65,0.91) | 0.377 | 3.1 | 0.80(0.69,0.94) | 0.198 | 35.7 |
HCC | 1015/999 | 0.74(0.47,1.19)b | 0.022 | 69 | 0.90(0.72,1.11) | 0.631 | 0 | 0.85(0.69,1.04) | 0.19 | 37 | 0.18(0.57,1.15)b | 0.037 | 64.6 |
Lung cancer | 2118/2103 | 0.77(0.65,0.91) | 0.895 | 0 | 0.90(0.77,1.04) | 0.098 | 57 | 0.85(0.74,0.98) | 0.289 | 19.4 | 0.83(0.73,0.95) | 0.281 | 21.3 |
Gastric cancer | 765/910 | 0.80(0.61,1.06) | 0.306 | 4.5 | 0.84(0.65,1.08) | 0.163 | 48.5 | 0.82(0.65,1.04) | 0.162 | 48.8 | 0.89(0.72,1.11) | 0.698 | 0 |
Other cancers | 3646/3975 | 1.06 (0.91,1.23) | 0.125 | 38.2 | 1.23(1.10,1.37) | 0.239 | 23.9 | 1.13(1.03,1.25) | 0.096 | 40.7 | 0.93(0.74,1.17) | 0.024 | 56.7 |
Ethnicities | |||||||||||||
Asian | 7837/8878 | 0.80(0.73,0.88) | 0.169 | 23.7 | 0.99(0.88,1.13)b | 0.001 | 57.4 | 0.95(0.84,1.07)b | 0.001 | 58.3 | 0.85(0.80,0.92) | 0.3 | 12.6 |
Caucasian | 4400/5395 | 0.94(0.71,1.23)b | 0.006 | 69.7 | 1.01(0.92,1.04)b | 0.597 | 0 | 0.98(0.90,1.07) | 0.181 | 32.3 | 0.94(0.74,1.21)b | 0.005 | 70.5 |
Source of controls | |||||||||||||
Population based | 11123/12811 | 0.87(0.77,0.98) b | 0.009 | 46.7 | 1.01(0.91,1.11)b | 0.002 | 52.4 | 0.97(0.88,1.06)b | 0.001 | 54.8 | 0.89(0.82,0.98) b | 0.024 | 41.1 |
Hospital based | 1540/1928 | 0.65(0.53,0.79) | 0.111 | 50 | 0.85(0.72,1.01) | 0.868 | 0 | 0.78 (0.67,0.92) | 0.585 | 0 | 0.74(0.63,0.87) | 0.092 | 53.5 |
P value of Q-test for heterogeneity test.
Random-effects model was used when a P value<0.05 for heterogeneity test; otherwise, fixed-effects model was used.
I 2: 0–25, no heterogeneity; 25–50, modest heterogeneity; 50, high heterogeneity.