TABLE 4.
Cox Proportional Hazards Regression Analysis Measured HRs (95% CIs) of Cancers by Zolpidem Dosage in Association With Using Zolpidem Alone and Using Both Zolpidem and Benzodiazepinea
| Zolpidem, mg/y | Overall |
Zolpidem only |
Zolpidem and benzodiazepine |
P value | |||
|---|---|---|---|---|---|---|---|
| No. of events/No. of patients | HR (95% CI) | No. of events/No. of patients | HR (95% CI) | No. of events/No. of patients | HR (95% CI) | ||
| 0 | 2924/59,800 | 1.00 (Reference) | 1316/35,336 | 1.00 (Reference) | 1608/24,464 | 1.47 (1.36-1.59)b | <.001 |
| 1-29 | 188/4578 | 0.99 (0.85-1.15) | 32/1211 | 0.92 (0.65-1.31) | 156/3367 | 1.45 (1.23-1.72)b | .04 |
| 30-299 | 413/5381 | 1.90 (1.70-2.13)b | 35/419 | 3.15 (2.25-4.41)b | 378/4962 | 2.64 (2.34-2.99)b | .50 |
| ≥300 | 446/4990 | 2.38 (2.12-2.67)b | 23/161 | 6.24 (4.13-9.43)b | 423/4829 | 3.30 (2.91-3.75)b | .049 |
a
CI = confidence interval; HR = hazard ratio.
b
P<.0001.