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. 2012 Jun;87(6):524–539. doi: 10.1016/j.mayocp.2012.02.017

FIGURE 2.

FIGURE 2

Summary of cardiac channel mutations in the catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1)–associated RYR2-encoded calcium release channel (cardiac ryanodine receptor) identified in a series of autopsy-negative sudden unexplained death (SUD). The putative, pathogenic SUD-associated mutations (gray circles) and nonsynonymous polymorphisms (white circles) identified in this study are depicted with their proximate location on the linear topologies (not drawn to scale) of the CPVT1-associated RYR2-encoded calcium release channel (cardiac ryanodine receptor) α-subunit. Asterisk indicates novel mutation. The numbers within parentheses represent the number of times the variant was seen in cases.